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Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulence factors in receiving rivers: Benefits of wastewater treatment plant upgrade

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1682-4

Abstract:

● Abundance of MAGs carrying ARG-VF pairs unchanged in rivers after WWTP upgrade.

Keywords： treatment plant upgrade     Antibiotic resistance genes (ARGs)     Virulence factors (VFs)     Gene co-occurrence     Genome-centric    

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Node Status Monitoring of Information-Centric Internet of Things

Cui Liqun, Wu Jun

Strategic Study of CAE 2020, Volume 22, Issue 6,   Pages 121-127 doi: 10.15302/J-SSCAE-2020.06.016

Abstract: text-align: justify;"> To manage the constantly changing network status information of the information-centricfor recording various network node status information, and adopts the naming format of information-centric

Keywords： information-centric networking，Internet of Things，node status monitoring，access control    

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Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 48-55 doi: 10.1007/s11684-012-0182-x

Abstract:

The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genomeComprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptomeThe present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides

Keywords： next-generation sequencing     cancer genome     whole genome sequencing     exome     transcriptome    

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dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 276-284 doi: 10.1007/s11684-021-0855-4

Abstract: We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia (GTN). In this trial (NCT01823315), 276 patients were analyzed. Patients were allocated to three initiated regimens: single-course methotrexate (MTX), single-course MTX+ dactinomycin (ACTD), and multi-course MTX (control arm). The primary endpoint was the complete remission (CR) rate by initial drug(s). The primary CR rate was 64.4% with multi-course MTX in the control arm. For the single-course MTX arm, the CR rate was 35.8% by one course; it increased to 59.3% after subsequent multi-course MTX, with non-inferiority to the control (difference –5.1%, 95% confidence interval (CI) –19.4% to 9.2%, P=0.014). After further treatment with multi-course ACTD, the CR rate (93.3%) was similar to that of the control (95.2%, P=0.577). For the single-course MTX+ACTD arm, the CR rate was 46.7% by one course, which increased to 89.1% after subsequent multi-course, with non-inferiority (difference 24.7%, 95% CI 12.8%–36.6%, P<0.001) to the control. It was similar to the CR rate by MTX and further ACTD in the control arm (89.1% vs. 95.2%, P=0.135). Four patients experienced recurrence, with no death, during the 2-year follow-up. We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN.

Keywords： gestational trophoblastic neoplasia (GTN)     methotrexate (MTX)     dactinomycin (ACTD)    

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The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 171-180 doi: 10.15302/J-FASE-2019302

Abstract: However, new breeding methods combined with genome editing and somatic cell nuclear transfer or microinjectionRecent advances in precise genome editing technologies, especially clustered regularly interspaced shortnucleases and the state of the art and new insights into practical applications and social acceptance of genomeIt is concluded that the production of gene-edited ruminants is feasible and through improvements in genome

Keywords： bioreactors     breeding     engineered endonucleases     genome editing     ruminants    

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Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Frontiers in Energy 2013, Volume 7, Issue 3,   Pages 317-332 doi: 10.1007/s11708-013-0271-9

Abstract: Inspired by the Material Genome Initiative as issued in 2011 by the United States of America, a morespecific and focused project initiative was proposed in this paper—the liquid metal material genome aimedtheoretical strategies and experimental methods in the research and development of liquid metal material genomeThe liquid metal material genome proposal as initiated in this paper will accelerate the process of finding

Keywords： liquid metal material genome     energy material     material discovery     advanced material     room-temperature liquid    

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GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 309-311 doi: 10.15302/J-FASE-2022440

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Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 23-33 doi: 10.1007/s11684-017-0607-7

Abstract:

Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunityfor microbial genome.In recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resultedBacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirementsIn this review, we outline the significance and summarize the roles of bacterial genome sequencing in

Keywords： genome sequencing     genomic epidemiology     bacteria     surveillance     infectious diseases    

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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract: The advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity research

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

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A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 123-128 doi: 10.15302/J-FASE-2019309

Abstract:

The recent development of genome editing technologies has given researchers unprecedented power toThis mini-review briefly summarizes the development of major genome editing tools, focusing on the application

Keywords： animal model     CRISPR     genome editing     TALEN     ZFN    

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Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 121-122 doi: 10.15302/J-FASE-2019317

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Network Centric Warfare Operational Concept and Information Fusion Technology

Zhu Lin,Zhang Xiaonan,Xu Xingjie

Strategic Study of CAE 2005, Volume 7, Issue 3,   Pages 69-73

Abstract:

This paper discusses the key content of network centric warfare.pointed out that the information fusion technology is one of the biggest challenges, which network centriclast, the paper analyzes the developing directions of information fusion technology for the network centric

Keywords： network centric warfare     operational concept     information fusion    

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation    

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Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 148-160 doi: 10.15302/J-FASE-2019305

Abstract: Genome editing technology with its ability to directly introduce beneficial sequence variants offersThis review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated

Keywords： animal breeding     cattle     cloning     CRISPR/Cas9     cytoplasmic injection     embryo     genome editing     germline chimaeras    

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Fog Computing-Based Firewall in Information-Centric Networking

Liu Yi, Li Jianhua

Strategic Study of CAE 2020, Volume 22, Issue 6,   Pages 128-135 doi: 10.15302/J-SSCAE-2020.06.017

Abstract:

The information-centric network (ICN) provides network protocols orientedto information itself, including a content-centric subscription mechanism and semantic-led naming, routing

Keywords： information-centric networking     fog computing     interest flooding attack     firewall    

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Title Author Date Type Operation

Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulence factors in receiving rivers: Benefits of wastewater treatment plant upgrade

Journal Article

Node Status Monitoring of Information-Centric Internet of Things

Cui Liqun, Wu Jun

Journal Article

Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Journal Article

dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric

Journal Article

The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Journal Article

Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Journal Article

GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Journal Article

Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Journal Article

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Journal Article

Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Journal Article

Network Centric Warfare Operational Concept and Information Fusion Technology

Zhu Lin,Zhang Xiaonan,Xu Xingjie

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Journal Article

Fog Computing-Based Firewall in Information-Centric Networking

Liu Yi, Li Jianhua

Journal Article